Gut microbiota linked to cognitive dysfunction! Study: "Insufficient 2 species of bacteria" may increase brain amyloid deposition
Gut bacteria linked to dementia? Research says it’s related to Butyric acid bacteria and Ruminococcus
There are approximately 100 trillion bacteria in the adult body, of which up to 80% to 90% live in the intestines. The bacterial breakdown of the intestinal flora is almost the same as that of human cells. In recent years, the role of intestinal flora in regulating the development of the immune system and nervous system has gradually become clear. Some studies have also pointed out that intestinal flora imbalance is associated with neuropsychiatric diseases, including severe anxiety disorder, depression, and attention deficit hyperactivity disorder. (ADHD), Parkinson’s disease (Parkinson’s disease), and schizophrenia.
A study published at the 2023 Alzheimer’s Association International Conference (AAIC) also pointed out that intestinal flora imbalance is related to B-amyloid (Beta-amyloid), and B-amyloid is a lost protein. One of the most important biomarkers of dementia. The study recruited 140 middle-aged people with normal cognitive function (average age 56 years old) to participate in the trial and analyzed the relationship between the gut microbiome combination and brain B-amyloid. The results showed that the gut microbiota has anti-inflammatory benefits. Low levels of Butyric acid bacteria and Ruminococcus (Rg) were significantly associated with higher B-amyloid and Tau protein aggregation.
Not enough probiotics to increase intestinal permeability? Toxic substances flow through the brain
Butyric acid bacteria and Ruminococcus in the intestine can produce butyrate, which is considered to have neuroprotective effects. The research team said that this analysis proves that there is indeed a specific connection between the human gut and the brain. The reduction of some microflora strains whose functions have been identified may increase intestinal permeability (leaky gut), allowing More toxic substances affect the brain after metabolism, eventually causing the deposition of B-amyloid and tau proteins.
Percy Griffin, Director of Science Interactions at the Alzheimer’s Association, commented that this study is noteworthy because it attempts to track and define which specific gut bacteria are most associated with dementia risk. The Alzheimer’s Association is currently conducting a 2-year clinical trial to understand whether early behavioral intervention can help change the intestinal microflora ecology and intestinal bacterial changes, ultimately affecting brain health. Continuing to explore the link between the digestive system and long-term cognitive dysfunction may increase opportunities for future treatments for Alzheimer’s disease and other dementias.
The survival of probiotics requires the intake of prebiotics and fiber for a healthy gut
The importance of intestinal health and probiotic supplementation has become increasingly known. However, even if a large amount of probiotics is consumed, an intestinal environment suitable for intestinal bacterial colonization is still required to promote health. Experts recommend that you should avoid diets high in fat, sugar, fried foods and excessive amounts of meat.
On the contrary, probiotics need enough prebiotics and fiber. High-quality sources of prebiotics in daily life include beans, whole grains, bananas, onions, etc. Fresh vegetables and fruits are rich in fiber. A balanced intake of relevant nutrients can enhance the survival of intestinal probiotics. , build good intestinal flora.
Source:
Feed your gut - Harvard Health Publishing
The gut microbiome in Alzheimer’s disease:
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