The third dose of vaccine boosts antibody production! Chang Gung Test: Moderna is 4 times more than high-end
Chang Geng announced the third dose trial data and called for additional doses to combat mutant strain infections
The vaccination rate for the third booster dose of COVID-19 vaccine in Taiwan has exceeded 40% and is heading towards 50%. What is the effect of additives?
Linkou Chang Gung Memorial Hospital published the results of Taiwan’s first COVID-19 vaccine booster vaccination study, recruiting a total of 340 subjects, and found that no matter which brand of vaccine is used as a booster, it can effectively increase the antibodies in the subjects Generates effects and is more effective against Omicron variant viruses. As for the side effects after injection, the proportion of Moderna was the highest, and the proportion of high-end was the lowest.
Qiu Zhengxun, deputy director of Linkou Chang Gung Gung Memorial Hospital and host of the trial project, expressed the hope that this result will help Taiwan further promote the implementation of COVID-19 vaccines, and recommended that people should take an interval of 3 months after receiving the first two doses of the vaccine. - Receive the third dose of additional vaccination in 6 months to enhance the protective power of the vaccine on the human body and prevent infection by new coronavirus mutant strains.
3rd dose Moderna produces nearly 4 times more antibodies than high-end
Vice President Qiu Zhengxun pointed out that since December last year, Linkou Chang Gung Memorial Hospital has implemented medical care staff to receive two doses of adenovirus vector AZ vaccine (AZ+AZ), followed by mRNA vaccine (Modena, Pfizer) or protein subunit vaccine. (High-end) Conduct a clinical trial of the third dose of additional vaccination, and analyze the immune production and adverse reactions of the subjects one month after the third dose.
This study recruited a total of 340 medical caregivers who had received two doses of AZ vaccine as subjects, and were randomly assigned to receive Moderna full dose, Moderna half dose, Pfizer (BNT) or high-end vaccine as the first vaccination. Three booster doses.
Vice President Qiu Zhengxun said that two people who did not meet the conditions for admission were excluded from the analysis. The results of the study found that on the 28th day after the third dose was administered, no matter which brand of vaccine was used as a booster dose, all It can effectively increase the concentration of neutralizing antibodies in the blood of subjects and achieve the effect of antibody production in the body. The increase times are: 47.7 times for the full dose of Moderna, 39.8 times for the half dose of Moderna, 32.2 times for BNT, and 12.7 times for the high-end.
Moderna has the highest rate of side effects, no difference in booster dose of T cell vaccine
Regarding the Omicron variant virus currently circulating, research has also shown that the neutralizing antibodies produced after the third dose are more effective against Omicron than before vaccination. The T cell immune response related to the prevention of severe disease increased significantly in the four groups. The increase times were: 4.2 times for the full dose of Moderna, 3.9 times for the half dose of Moderna, 3.1 times for BNT, and 3.3 times for the high-end.
As for the side effects of vaccines after the third dose, Moderna had the highest proportion of side effects (local pain about 97-100%, fever about 15.3-29.5%), and the high-end vaccine had the lowest proportion of side effects (local pain 76.5%). , fever 4.8%).
Vice President Qiu Zhengxun said that it can be seen from the experimental results that for medical caregivers who have received two doses of AZ vaccine, no matter which brand of vaccine is used as a booster dose, the serum antibody production one month after the administration, or Cellular immune responses were significantly improved.
In terms of the increase in antibodies, the mRNA vaccine is still better than the protein subunit vaccine; there is no significant difference in T cell immune response between different vaccine supplements.
Further reading:
