Is China's "sub-protein vaccine" a surprise success? Research shows that the concentration of neutralizing antibodies has greatly increased! Extending the vaccination schedule is more effective
Will Sinovac and Sinopharm have “almost no” antibodies to Omicron and the “Zhikweide” vaccine have different answers?
Omicron viruses continue to wreak havoc around the world. The U.S. Centers for Disease Control and Prevention (CDC) has recently confirmed that vaccination with the third dose of the mRNA vaccine provides about 90% protection against Omicron viruses. Is the “live-attenuated vaccine” manufactured and exported by China, another powerful country in the world, suitable for use as the third booster dose?
The authoritative journal “Nature” has published a study pointing out that the live-attenuated vaccines produced in China (such as the Sinovac and Sinopharm vaccines) have not detected effective neutralizing antibodies against Omicron in patients with new coronavirus pneumonia. However, if the third dose of the vaccine is administered with China’s self-developed thorn unit protein vaccine-“Zhikweide”, maybe there will be a different answer?
Is the neutralizing antibody positive rate among those who received the third dose of Chikvader “100%”?
The latest study published in “The New England Journal of Medical” shows that the Omicron neutralizing antibody concentration test was conducted on the subunit protein vaccine “Zhiqiweide” combined with live attenuated vaccine. All subjects had received two doses of Sinopharm or Sinovac vaccines before the experiment, and were scheduled to receive Zhikvaide in the third dose.
A team from the Chinese Academy of Sciences divided the subjects into 3 groups:
Those who have recovered from COVID-19 and are infected with Omicron virus again.
There is an interval of 1 month between the second and third doses of vaccine.
There is an interval of 4 months between the second and third doses of vaccine.
The team used a pseudovirus (Pseudovirus) neutralizing system test to detect the concentration of neutralizing antibodies in the subjects. Among the 16 serum samples from people who recovered from COVID-19, 15 showed negative for neutralizing antibodies, indicating that the immune escape rate of Omicron virus is extremely high.
However, the concentration of neutralizing antibodies in the bodies of subjects in Groups 2 and 3 increased significantly after administration of Chikvader vaccine. Among the subjects who received 3 doses of the vaccine, about 62% had a positive reaction for neutralizing antibodies; the probability of a positive reaction for neutralizing antibodies was 56% for subjects in Group 2, and 56% for subjects in Group 3. More than 100%.
Research shows that the “interval time” between the second and third doses is key? Is it more effective to vaccinate after 4 months?
In order to further understand the differences between Group 2 and Group 3, the research team launched long-term follow-up on those who had previously received live-attenuated vaccines and had a 4-month interval between vaccinations. They found that after 4-6 months, the probability of such injectors still having neutralizing antibodies in their bodies was 69%, which means that extending the vaccination time of the second and third doses may be more effective and long-term. Maintain neutralizing antibodies in the body to fight against Omicron viruses.
Research results show that the second dose of live attenuated vaccine and the third dose of unit protein vaccine may be able to effectively increase the concentration of neutralizing antibodies in the body and effectively inhibit Omicron virus. In addition, studies also believe that the time between the second and third doses of vaccine may change the concentration of neutralizing antibodies. The concentration of neutralizing antibodies in the body of those vaccinated more than 4 months apart was significantly higher than that of those vaccinated 1 month apart.
However, this study was limited to the Sinovac, Sinopharm, and Chevron vaccines produced in China. Whether live-attenuated vaccines will also produce a certain concentration of neutralizing antibodies when used in conjunction with other subunit protein vaccines remains to be confirmed by other studies. Is the conclusion that extending the interval between two doses can increase the concentration of neutralizing antibodies applicable to other vaccine types such as mRNA vaccines and adenovirus vaccines? These are still unknown issues and require further research.
Source:
Effects of a Prolonged Booster Interval on Neutralization of Omicron Variant
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