Too much caffeine linked to cardiovascular disease? Study reveals: Drinking "2 large iced lattes" a day is risky

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Too much caffeine linked to cardiovascular disease? Study reveals: Drinking "2 large iced lattes" a day is risky

Coffee is recognized as one of the beverages that is good for the body, but if consumed in excess, it may cause cardiovascular-related problems. A recent study released by the American Heart Association (ACC) shows that drinking more than 400 mg of caffeine per day may increase the risk of cardiovascular disease in healthy people. Research warns that drinking more than 2-3 cups of coffee, 10 cans of soda or 2 cans of energy drinks a day may cause cardiovascular harm.

Too much caffeine linked to cardiovascular disease? Study: Drinking 2 lattes a day can be risky

A research team from Zadus Medical College in India recruited 92 middle-aged subjects aged 18-45 years old. All of their blood pressure values ​​were normal and they were generally healthy. The research team further evaluated whether the subjects had long-term high-dose caffeine intake; high-dose caffeine was defined as “consuming any caffeinated beverages 5 days a week for more than 1 year.”

After investigation, the caffeinated drinks commonly consumed by the subjects include tea, coffee, carbonated drinks, cola, soda, energy drinks, etc. The test results showed that 19.6% of the subjects consumed more than 400 mg of caffeine per day. The operation of the autonomic nervous system has been seriously affected, and the heart rate and blood pressure increased significantly. Those who consumed more than 600 mg had to wait until they completed the 3-minute step test. Finally, even after 5 minutes of rest, the heart rate and blood pressure continued to rise.

In this trial, those with the highest caffeine intake were mostly women, those working in business management positions, and those living in cities. Nency Kagathara, the lead author of the study, said that due to the impact of caffeine on the autonomic nervous system, long-term excessive caffeine intake may put otherwise healthy people at risk of hypertension and other cardiovascular events.

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Kagathara pointed out that according to the above-mentioned studies, excessive caffeine intake may lead to an increased risk of “hypertension” and lead to other problems: “Hypertension is associated with an increased risk of coronary artery disease, heart failure, chronic kidney disease, and dementia. It weakens the heart over time and is one of the major risk factors for heart disease.”

In addition to caffeine intake, there are other factors that may lead to high blood pressure, such as alcohol intake, smoking, age, family history, and high sodium intake. If excessive caffeine intake is combined, the risk may increase. Kagathara also stated that the sample size in this trial was too small and the ethnic diversity was insufficient, so larger studies are needed to clarify the association between caffeine overdose and cardiovascular disease.

Will drinking too much coffee lead to kidney failure? Drinking more than 3 cups increases the risk by 2.7 times

Excessive consumption of caffeine may cause more serious consequences in certain ethnic groups? The authoritative journal “JAMA Network Open” published a study in the past that pointed out that subjects with mutations in the “CYP1A2 gene” in their bodies may make it difficult for caffeine to be metabolized in the body. If this group drinks more than 3 cups of coffee a day, it may lead to problems such as proteinuria, low glomerular filtration rate and high blood pressure.

Research also points out that people with slow caffeine metabolism who drink more than three cups of coffee a day are 2.7 times more likely to suffer from kidney dysfunction and 2.8 times more likely to suffer from high blood pressure. Research suggests that mutations in the CYP1A2 gene may make it difficult to metabolize caffeine, thereby damaging the kidneys or cardiovascular system. About half of the subjects in the trial carried the “rs762551 variant” of the CYP1A2 gene, which may be a potential cause of low caffeine metabolism.

The study authors stated that for those who carry mutated genes, coffee may indeed damage the kidneys; as for cola, tea, energy drinks, etc., it is still not possible to confirm their risk to the kidneys, but if the caffeine level is higher than that of ordinary commercially available Coffee may also be harmful to the kidneys. It is worth mentioning that some literature in the past believed that Asians have poor metabolism of caffeine and low tolerance to coffee.

The public is reminded that according to content published by the Taiwan Ministry of Health and Welfare, the daily intake of caffeine is recommended to be less than 300 mg, which will not have any impact on health. The caffeine content of a large cup of Americano is about 270 mg, and that of a large latte is 200 mg. It is recommended that no matter what kind of coffee you drink, you should drink no more than 2 cups; you should also pay attention to pairing it with other caffeine-containing drinks. There is still a possibility of exceeding the standard.

For those with cardiovascular disease, arrhythmias, iron deficiency anemia, gastrointestinal diseases, long-term insomnia, pregnant women and children, it is best to avoid or reduce the consumption of caffeinated drinks. For those who already have osteoporosis, if they still want to drink coffee, they should supplement with more calcium to avoid exacerbating calcium loss.

Source:

Be aware of the caffeine content when purchasing to protect your health and mine

Coffee, CYP1A2 genotype, and risk of myocardial infarction

CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction

New Study Finds Chronic High Caffeine Consumption May Heighten Risk for Cardiovascular Disease

Chronic High Caffeine Consumption Impacts Heart Rate, BP Post Activity, Heightens Risk For CVD

The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis


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